systems and methods for cleaning surfaces

专利摘要:
The present invention relates to surface cleaning systems and methods such as hands. In general, the described techniques utilize a system that includes a housing having an active agent receptacle in fluid communication with at least one nozzle, and an air pump in fluid communication with at least one nozzle. The system also includes a control module configured to control delivery of an active agent such as an aerosol spray through at least one nozzle at a delivery dose. the delivery dose is expelled over the surface as a thin uniform layer and dried so that the entire surface sanitization process is completed in less than or equal to 5 seconds. The active agent receptacle may be configured to receive a removable, replaceable cartridge that carries the active agent.
公开号:BR112017025129A2
申请号:R112017025129-9
申请日:2016-05-23
公开日:2019-11-12
发明作者:L Carvalho Bruce；D Cosman Maury
申请人:Livonyx Inc；
IPC主号:

专利说明:

Invention Patent Specification Report for
SYSTEMS AND METHODS FOR HYGIENIZING SURFACES.
Cross Reference to Related Applications [001] This application claims priority for US Provisional Patent Application Number 62 / 166,007, entitled Skin Hygiene Apparatus and Method filed on May 24, 2015, and US Provisional Patent Application Number 62 / 197.067, entitled Apparatus and Method for Hygienic Skin deposited on July 25, 2015, which are incorporated herein by reference in their entirety.
Field [002] This description refers to systems and methods for cleaning surfaces.
Background [003] Human diseases are often caused by pathogenic microorganisms that represent the largest categories of bacteria, viruses and fungi. The movement of an infectious particle from an infected host or individual to a new susceptible victim can occur by several mechanisms, including breathing aerosolized fluids from the host, contact with surfaces contaminated by the host and body fluids from the host, or by hand transfer. of the victim or third parties of the host or contaminated surfaces for the victim. The specific transfer mechanism depends on the organism as well as the specific environment. In hospitals and other clinical settings transference over the hands of caregivers is considered a potentially important mechanism for organisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species (collectively known as ESKAPE pathogens) and Clostridium difficile.
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2/64
In addition, multiple drug resistant organisms (MDROs), defined as microorganisms, predominantly bacteria, which are resistant to one or more classes of antimicrobial agents, have a special clinical significance due to their acquired resistance. MDROs include but are not limited to Methicillin Resistant
S. aureus (MRSA), Resistant to Carbapenema Enterobacteriaceae (CRE), Resistant to Multiple drugs A. baumannii (MDR-Ab), and Resistant to Vancomycin Enterococcus (VRE). The number of viable organisms and the contact site required to initiate an infection in a new host depends on the infectivity of the organisms as well as the immune capacity of the new potential host. Individuals with impaired or weakened immune function, such as hospital patients, are typically more likely to become hosts for new infections. Hospital-acquired infections have become a significant problem for the healthcare industry. The severity of this problem is likely to continue to increase as additional pathogens with antibiotic resistance emerge.
[004] Some microorganisms, such as norovirus, an intestinal pathogen, are a significant concern in the cruise ship industry and in domestic assisted care / nursing environments, where spread can be rapid within a crowded community. The illnesses caused can be life threatening. The food preparation industry, for example, large-scale poultry packaging facilities, is periodically linked to outbreaks of antibiotic-resistant Salmonella enterica, causing numerous deaths. The role of manual contact in the dispersion and transmission of norovirus and salmonella organisms in these environments is likely to be significant.
[005] The importance of good manual hygiene in clinical settings and food preparation is well established, typical
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3/64 promoted in terms of hand washing or use of topical alcohol-containing gels. Conventional proposals, however, have certain limitations. Hand washing can remove contaminating surface organisms without causing significant damage to native organisms found on the skin of healthy individuals. To be effective, hand washing should take 30 seconds. However, this amount of time is prohibitive in fast-paced, high-stress critical care environments, and does not allow additional time for hand drying. The availability of sinks can also limit the use of this proposal. Although supplying, applying, and drying an alcohol gel on your hands can be performed significantly faster than hand washing and drying, these steps also require a relatively long time of approximately 10-15 seconds.
[006] Consequently, there is a need for improved techniques and devices to sanitize surfaces and hands in healthcare, homes and other environments.
Summary [007] In some respects, a system for exterminating or inactivating a pathogen is provided that can include a housing that has an active agent receptacle in fluid communication with at least one nozzle, an air pump in fluid communication with the at least one mouthpiece; and a control module configured to control delivery of an active agent such as an aerosol through at least one nozzle in a delivery dose. The system is configured to deliver the delivery dose to a target surface as a thin, uniform, dry coating over a period of time that is less than or equal to 5 seconds. The surface can be any suitable surface. For example, this can be a surface of one or both hands.
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4/64 [008] The system can vary in any number of modes. For example, the system may also include an air tank configured to provide air for at least one nozzle. The system may also include a pressure regulator configured to control the pressure in at least one nozzle. As another example, the system can also include a display communicatively coupled to the control module and configured to display information related to the operation of the system. The display can be any suitable display and, in some modalities, it can be an interactive display configured to receive instructions regarding the operation of the system.
[009] The system may include at least one sensor configured to detect the presence of the target surface in the vicinity of at least one nozzle. The at least one sensor can be an optical motion sensor or any other sensor.
[0010] In some embodiments, the system includes a drying component configured to dry the delivery dose supplied to the target surface. In some embodiments, the system may include a pressure-based fluid pump.
[0011] In some embodiments, the active agent receptacle houses a cartridge that contains removable and refillable reagent. In other embodiments, the active agent receptacle is configured as a reservoir that receives a supply from the active agent. [0012] The active agent can include any one or more ingredients. For example, it can be selected from the group consisting of an aqueous solution of hydrogen peroxide, an aqueous solution of hypochlorous acid, an aqueous solution of isopropyl alcohol, an aqueous solution of ethanol, an aqueous solution of peracetic acid, an aqueous solution of acetic acid, an aqueous solution of sodium hypochlorite, an aqueous solution of ozone, and any combination thereof. In some modalities, the active agent
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5/64 may include an aqueous mixture of peracetic acid and hydrogen peroxide.
[0013] The active agent can have any suitable concentration of one or more ingredients. For example, in some embodiments, the aqueous solution of hydrogen peroxide may have approximately 0.3% to approximately 15% hydrogen peroxide. In other embodiments, the aqueous hydrogen peroxide solution may have approximately 0.33%, 1%, 3%, 6%, 9%, or 12% hydrogen peroxide.
[0014] The aqueous hypochlorous acid solution may have approximately 0.046% hypochlorous acid. The aqueous solution of isopropyl alcohol can have at least approximately 70% isopropyl alcohol.
[0015] The at least one nozzle can vary in many different ways. For example, the at least one nozzle can have a single stationary nozzle. In other embodiments, the at least one nozzle may be two or more stationary nozzles, or two or more movable nozzles. In some embodiments, the at least one mouthpiece may be an ultrasonic mouthpiece. In other embodiments, the at least one nozzle may be an atomization nozzle based on airflow.
[0016] In some embodiments, the system may include at least one actuator configured to receive user input to activate at least one nozzle. The at least one nozzle can be configured to deliver a uniform layer of the active agent to the target surface, the uniform layer having a thickness of approximately 1 pm to approximately 50 pm. In some embodiments, the uniform layer has a thickness of approximately 5 pm to approximately 20 pm.
[0017] In some respects, a method for exterminating or inactivating pathogens on a surface is provided. The method can inPetição 870180001867, from 01/09/2018, p. 8/105
It is possible to spray an aerosolized layer of an active agent over the surface, the layer being a thin and substantially uniform coating. Spraying can take place over a first period of time and the aerosolized layer is effective for drying over a second period of time while being effective for exterminating or inactivating the pathogen on the surface, and in which a duration of the first and second periods of time is less than 5 seconds.
[0018] The method can vary in many different ways. For example, pathogens can include bacteria, viruses, fungi, their spores or any combination thereof. The bacterium can include Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter, Pseudomonas aeruginosa, and Enterobacter (ESKAPE). As another example, the bacterium can include at least one from Escherichia coli, Salmonella enterica, and Listeria monocytogenes. Viruses can be non-enveloped viruses, which can include norovirus, rhinovirus, coxsackievirus, rotavirus or any combination thereof. Viruses can also include enveloped viruses, which can include influenza viruses. The spore can include Clostridium difficile spores.
[0019] The duration of the first and second time periods may vary. For example, the duration of the first and second time periods can be less than 3 seconds. In some cases, the first period of time is approximately 1 second or less. In some cases, the second time period is approximately 2 seconds or less.
[0020] The active agent layer can be from approximately 1 pm to approximately 50 pm in thickness.
[0021] In one aspect, the techniques described provide a method that includes, when a hand or hands placed adjacent to a mouthpiece is detected, providing a thin, uniform layer of inactive fluidPetition 870180001867, from 09/01/2018, pg. 9/105
7/64 tion of pathogen or germicidal fluid over the surfaces of the hand or hands, followed by allowing the fluid to dry. This process is completed within a short time, preferably less than 5 seconds.
[0022] In another aspect, the techniques described provide a low volume (and consequently a low dose) but effective application of pathogen or germicidal inactivation fluid on the skin. The low dose of an active agent provides minimal irritation or toxicity to the skin. The use of the low dose of the active agent expands a set of safe, non-irritating and non-toxic fluids in addition to antiseptic fluids to include disinfectant fluids that are normally used to inactivate or exterminate pathogens on inanimate surfaces.
[0023] In another aspect, a method is provided that includes providing the layer provided with pathogen inactivating fluid or germicidal fluid that is thin enough to dry properly by evaporation in less than 5 seconds.
[0024] In another aspect, a method is provided where the drying of pathogen inactivation fluid or germicidal fluid is aided by aspiration of air through the hands or by exposure of the hands to infrared radiation.
[0025] In another aspect, control of the drying process and the time over which the hands are wet is used to control the duration over which the pathogen inactivation fluid or germicidal fluid is effective.
[0026] In another aspect, control of the drying process and the time over which the hands are wet is used to minimize the effects of skin irritation and potential toxicity of the pathogen inactivation fluid or germicidal fluid by stopping its activity through drying of the fluid.
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8/64 [0027] In another aspect, control of the drying process and the time over which the hands are wet is used to minimize damage to the microflora residing on the skin.
[0028] In one aspect, the method described is effective in inactivating or exterminating a variety of types of pathogens, including bacteria, fungi, viruses or spores. In another aspect, this method includes selectively inactivating or exterminating pathogens on the surface of the hands while not substantially inactivating or exterminating the resident microflora of the hands.
[0029] In another aspect, the techniques described are effective in inactivating or exterminating a variety of strains of bacterial pathogens such as, for example, the pathogens ESKAPE, Escherichia coli, Salmonella enterica, and Listeria monocytogenes.
[0030] In some respects, the techniques described are effective in inactivating or exterminating non-enveloped viruses such as norovirus, rhinovirus, coxsackievirus and rotavirus. In other respects, the techniques described are effective in inactivating or exterminating enveloped viruses such as influenza viruses. In still other aspects, the techniques described are effective in inactivating or exterminating Clostridium difficile spores.
[0031] In some respects, the active agent includes a pathogen inactivating fluid or germicidal fluid that is an aqueous solution of hydrogen peroxide.
[0032] In one embodiment, the pathogen inactivation fluid or germicidal fluid is an aqueous solution of hypochlorous acid.
[0033] In another embodiment, the pathogen inactivation fluid or germicidal fluid is an aqueous solution of isopropyl alcohol.
[0034] In another embodiment, the pathogen inactivation fluid or germicidal fluid is an aqueous solution of ethanol.
[0035] In another embodiment, the pathogen inactivation fluid or
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9/64 germicidal fluid is an aqueous solution of peracetic acid.
[0036] In another embodiment, the pathogen inactivation fluid or germicidal fluid is an aqueous solution of acetic acid.
[0037] In another embodiment, the pathogen inactivation fluid or germicidal fluid is an aqueous solution of sodium hypochlorite.
[0038] In another embodiment, the pathogen inactivation fluid or germicidal fluid is an aqueous ozone solution (or ozonized water).
[0039] In another embodiment, the pathogen inactivation fluid or germicidal fluid is a mixture of ozonized water and aqueous hydrogen peroxide.
[0040] In another embodiment, the pathogen inactivation fluid or germicidal fluid is an aqueous mixture of peracetic acid and hydrogen peroxide.
[0041] In some respects, an atomization spray system based on airflow is provided that can provide the thin, uniform layer of an active agent that includes a pathogen inactivation fluid or germicidal fluid to a hand surface.
[0042] In other respects, the pressure-based atomization spray system is provided that can provide a thin, uniform layer of pathogen inactivation fluid or germicidal fluid to a hand surface.
[0043] In other respects, an ultrasonic spray system is provided that can provide a thin, uniform layer of pathogen inactivation fluid or germicidal fluid to a hand surface.
[0044] In some embodiments, the described system incorporates a fan to push or pull air through the hands in order to accelerate the drying of pathogen inactivation fluid or germicidal fluid.
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10/64 [0045] In some embodiments, the described system incorporates a combination of heater and fan to push heated air through the hands in order to accelerate the drying of pathogen inactivation fluid or germicidal fluid.
[0046] In some embodiments, the described system provides infrared heat to the hands in order to speed up the drying of pathogen inactivation fluid or germicidal fluid.
[0047] In some embodiments, an air atomization spray system is provided that can provide a coating layer of pathogen inactivation fluid or germicidal fluid that is approximately 4 pm to approximately 10 pm thick for a hand surface . The coating, which can be dried within 5 seconds, is effective against one or more strains of Escherichia coli.
[0048] It should be appreciated that although the techniques provided herein are described as being used to sanitize one or both hands as a target surface, the techniques can be applied to any other target surface, including any inanimate surface.
Brief Description of the Drawings [0049] The modalities described above will be more fully understood from the following detailed description taken in conjunction with the accompanying drawings. The drawings are not intended to be drawn to scale. For the sake of clarity, not all components can be identified in each drawing. In the drawings:
[0050] Figure 1 is a schematic diagram of a system in which the described techniques can be implemented;
[0051] Figure 2 A is another schematic diagram of a system in which the described techniques can be implemented;
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11/64 [0052] Figure 2B is another schematic diagram of a system in which the described techniques can be implemented;
[0053] Figure 2C is another schematic diagram of a system in which the techniques described can be implemented;
[0054] Figure 3 is a schematic illustration of a system that has a stationary nozzle that can deliver an active agent to a surface such as a hand;
[0055] Figure 4 is a schematic illustration of a system that has a network of nozzles that can deliver an active agent to a surface such as a pair of hands;
[0056] Figures 5A-5C are schematic illustrations of a mobile network of nozzles that can be used with a sanitizing system to provide an active agent for a surface such as a pair of hands;
[0057] Figure 6 is a flow chart of a method for cleaning a surface according to the techniques described;
[0058] Figure 7 is a flow chart of a method for cleaning a surface according to the techniques described;
[0059] Figure 8 is an image of an agar plate that shows the results of an experiment that demonstrates the effectiveness of an application of an active agent over fingers coated with bacteria;
[0060] Figure 9 is another image of an agar plate showing the results of another experiment that demonstrates the effectiveness of an application of an active agent over fingers coated with bacteria;
[0061] Figure 10 is an image of an agar plate showing the results of an experiment that demonstrates substantial bacterial growth on membranes exposed to a bacterial solution diluted 10,000 times;
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12/64 [0062] Figure 11 is another image of an agar plate showing the results of another experiment that demonstrates substantial bacterial growth on membranes exposed to a bacterial solution diluted 10,000 times;
[0063] Figure 12 is an image of an agar plate showing the results of another experiment that demonstrates moderate bacterial growth on membranes exposed to a bacterial solution diluted 100,000 times;
[0064] Figure 13 is an image of an agar plate showing the results of another experiment that demonstrates limited bacterial growth on membranes exposed to a bacterial solution diluted 1,000,000 times;
[0065] Figure 14 is an image of an agar plate showing the results of an experiment that shows no bacterial growth on membranes exposed to a bacterial solution diluted 10,000 times when an aqueous solution of 3% hydrogen peroxide was used to treat membranes;
[0066] Figure 15 is an image of an agar plate showing the results of an experiment that shows no bacterial growth on membranes exposed to a bacterial solution diluted 100,000 times when an aqueous solution of 3% hydrogen peroxide was used to treat membranes;
[0067] Figure 16 is an image of an agar plate that shows the results of an experiment that shows no bacterial growth on membranes exposed to a bacterial solution diluted 1,000,000 times when an aqueous solution of 3% hydrogen peroxide was used to treat the membranes;
[0068] Figure 17 is an image of an agar plate showing the results of an experiment that shows no bacterial growth on membranes exposed to a bacterial solution
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13/64 in diluted 10,000 times when an aqueous solution of 1% hydrogen peroxide was used to treat the membranes;
[0069] Figure 18 is an image of an agar plate showing the results of an experiment that demonstrates limited bacterial growth on membranes exposed to a bacterial solution diluted 10,000 times when an aqueous solution of 0.33% hydrogen peroxide was used to treat membranes;
[0070] Figure 19 is an image of an agar plate showing the results of an experiment that shows no bacterial growth on membranes exposed to a diluted bacterial solution 10,000 times when a dilute aqueous solution of hypochlorous acid was used to treat the membranes ;
[0071] Figure 20 is an image of an agar plate showing the results of an experiment showing limited bacterial growth on membranes exposed to a diluted bacterial solution 100,000 times when the diluted aqueous solution of hypochlorous acid was used to treat the membranes ;
[0072] Figure 21 is an image of an agar plate showing the results of an experiment that does not show any bacterial growth on membranes exposed to a diluted bacterial solution 1,000,000 times when the diluted aqueous solution of hypochlorous acid was used to treat membranes;
[0073] Figure 22 is an image of an agar plate showing the results of an experiment that shows no bacterial growth on membranes exposed to a bacterial solution diluted 10,000 times when an aqueous solution of 70% isopropyl alcohol was used to treat the membranes;
[0074] Figure 23 is an image of an agar plate showing the results of an experiment that does not show any bacterial growth on membranes exposed to a bacterial solution
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14/64 in diluted 100,000 times when an aqueous solution of 70% isopropyl alcohol was used to treat the membranes;
[0075] Figure 24 is an image of an agar plate showing the results of an experiment that shows no bacterial growth on membranes exposed to a bacterial solution diluted 1,000,000 times when an aqueous solution of 70% isopropyl alcohol was used to treat membranes; and [0076] Figures 25A-25E show membrane images, where each membrane is pre-deposited with approximately 30,000 Bacillus subtilis spores and treated with (A) aqueous hydrogen peroxide solution that has 12% hydrogen peroxide concentrations, (B) aqueous hydrogen peroxide solution which has 9% concentrations of hydrogen peroxide, (C) aqueous hydrogen peroxide solution which has 6% concentrations of hydrogen peroxide, (D) aqueous hydrogen peroxide solution which has 3 % concentrations of hydrogen peroxide, and (E) distilled water.
Detailed Description [0077] Certain exemplary modalities will now be described to provide a general understanding of the principles of the systems and methods described here. One or more examples of these modalities are illustrated in the accompanying drawings. Those skilled in the art understood that the systems and methods specifically described and illustrated in the accompanying drawings are exemplary non-limiting modalities and that the scope of the modalities is defined only by the claims. In addition, the features illustrated or described in connection with an exemplary modality can be combined with the features of other modalities. Such modifications and variations are intended to be included within the scope of the described modalities.
[0078] The modalities described here generally refer to system 870180001867, of 01/09/2018, p. 10/175
15/64 themes and methods for cleaning surfaces, including body surfaces such as, for example, hands, in various environments. The techniques described involve providing a uniform, thin layer of an active agent to a target surface being treated in a way that allows inactivation or extermination, surface microorganisms, or transients. The active agent is delivered to a target surface quickly and in a controlled manner, and it quickly dries over the treated surface as well. Specifically, in some instances, the agent is delivered over the surface in less than one or two seconds or less than half a second, and it can be dried on the surface within a few seconds or less than a second. For example, in some embodiments, the entire sanitizing process that involves delivering an active agent to a target surface and drying the active agent can take less than ten seconds. In other modalities, the cleaning process can take less than five seconds. In still other modalities, the cleaning process can take less than three seconds. Thus, the target surface can be reliably cleaned in a matter of seconds.
[0079] The active agent, as used herein, is a single ingredient or a mixture of two or more ingredients such as antiseptic or disinfectant agents that inactivate or exterminate a variety of types of transient pathogens, including bacteria, fungi, viruses or spores. In some respects, the active agent that can be applied to selectively inactivate hand hygiene or wipe out the transient pathogens on the surface of the hands while not substantially affecting the viability of resident microflora of the hands.
[0080] The systems and methods described here have a number of advantages. Specifically, as mentioned above, the process of covering a target surface with an active agent can be completed
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16/64 in less than ten, or even less than three to five seconds. Such improved time in the process of cleaning the surface, and, more specifically, hand washing can be especially advantageous in a health care environment or another where timely and frequent hand washing is essential. In addition, the active agent can be delivered to a surface being treated as a low dose without compromising the effectiveness of the agent's sanitizing action. This can be specifically beneficial when the active agent is delivered to the hands. Specifically, the low dose provides less irritation or toxicity to the skin and thus allows for repeated application of the agent to maintain the proper sanitary condition of the person's hands. For example, a health worker can clean his hands multiple times during the day without inconvenience or become uncomfortable. This can also improve health professionals' compliance with hand hygiene standards, which can substantially reduce hospital infections and thus save lives. In addition, as the way in which active agents can be delivered using the techniques described, in some environments, more aggressive active agents can be used than those that would typically be used to prevent excessive skin irritation. At the same time, as mentioned above, the described cleaning process can be smoother on the natural (resident) microflora of the hand.
[0081] The techniques described can be used in conjunction with a variety of surfaces, including inanimate surfaces and surfaces of human body parts, such as, for example, hands (or with or without gloves), and in a variety of different environments . [0082] The system that can implement surface cleaning techniques can have several components and this can atomize the active agent using a number of different proposals. IndepenPetição 870180001867, from 01/09/2018, p. 10/195
17/64 regardless of its specific configuration, and type and number of components, the system operates to deposit an active agent on a target surface in the form of an aerosol spray. A variety of technologies can be used in the system to produce the aerosol spray.
[0083] Before describing the examples of the techniques presented here, non-limiting definitions of certain terms as used herein are provided. Thus, the term resident microflora refers to the community of resident microorganisms that are considered to be permanent inhabitants of the skin. These resident microorganisms are found on or within the epidermal layer of the skin.
[0084] The term pathogens refers to bacteria, fungi, viruses or spores that are capable of causing disease. The term transient pathogens refers to pathogens found on the outer layer of the skin, where they do not normally reside. Transient pathogens are typically deposited on the skin through direct contact with a contaminated surface.
[0085] Figure 1 generally shows a modality of a system 100 for cleaning surfaces in which the described techniques can be implemented. System 100 has a housing 102 that includes a controller 104, an active agent receptacle 106, an active agent supplier 108, a sensor 110, the drying component 112, and an optional overspray collector 115. It should be appreciated that housing 102 may include other components that are not shown in Figure 1 for the sake of simplicity. Thus, system 100 includes one or more components of aerosolization, or atomization, configured to transform an active agent present in the active agent supplier 108 into an aerosol. The system can be an atomization spray system based on
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18/64 air, a pressure-based atomization spray system, an ultrasound spray system, or another type of atomization system. Also, not all of the communicative connections that exist between the components shown in Figure 1 and other components are shown in Figure 1.
[0086] System 100 can be stationary - for example, it can be configured to be attached to a wall or other surface. In some cases, system 100 may be mobile. Also, system 100 can be part of another system that includes other components. As an example, the system 100 may be part of a mobile cart that may have, in addition to the system 100, a glove storage compartment, a supply of an active agent, and any other features relating to hand hygiene.
[0087] In this example, system 100 includes sensor 110 which can be associated with housing 102 in various modes and which can be used to determine that system 100 must be activated to sanitize a target surface. In some embodiments, sensor 110 may be a proximity sensor that detects that the target surface is in proximity to active agent supplier 108. It should be appreciated, however, that sensor 110 is shown as an example only. Thus, in some embodiments, another trigger mechanism can be used in addition or alternatively to activate the system 100 to perform a targeted surface cleaning process. For example, system 100 can be associated with a pedal, one or more buttons, or one or more other suitable mechanism (s) ^) that can receive a command (for example, user input) to start the system 100. Furthermore, system 100 can be configured so that it can be activated in response to a voice command, an instruction received via a touch screen display or a sensor, or in any other mode.
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19/64 [0088] The target surface can be any suitable surface. In the examples illustrated here, the target surface is one hand or both hands of a person. The hand (s) may be gloved or the target surface may be the skin surface. It should be appreciated that any other surface can be cleaned using the 100 system. The target surface can be brought close to the active agent supplier 108. For example, one or both hands can be placed in a suitable location close to the supplier active agent 108. Furthermore, in implementations in which system 100 or a similar system according to the techniques described is portable, system 100 can be brought to a location on the surface being sanitized.
[0089] The active agent receptacle 106 can be configured as a reservoir that can receive and store the active agent. The active agent can be created in situ and delivered to the reservoir. In some embodiments, the active agent receptacle 106 can accommodate a cartridge that contains removable and refillable reagent 107. However, in some cases, the cartridge may be disposable and non-refillable. The cartridge 107 can be configured to mount removable within the active agent receptacle 106 so that the active agent of the cartridge 107 can be accessed by the system and provided to the nozzles as required.
[0090] Supplier component 108 includes one or more spray nozzles 114 configured to deliver the active agent in the form of an aerosol once the surface to be treated is detected by sensor 110 or when system 200 is activated in any other properly. Nozzles 114 can be arranged to deliver the active agent in a desired manner over a targeted surface. The operation of the supplier 108 is controlled by the controller 104. The spray nozzles 114 can be stationary or mobile,
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20/64 as discussed in more detail below. Regardless of their specific arrangement, configuration, and number, the spray nozzles 114 are controlled by controller 104 to provide a certain amount of the active agent as an aerosol dosage.
[0091] The drying component 112 of the housing 102 can be activated by the controller 104 in response to the detection of the target surface in the vicinity of the housing 102. The drying component 112 can have a variety of different configurations. For example, it can be configured as a fan / dryer that can provide a directed air flow so that the target surface sprayed by the active agent supplied from the nozzles 114 is dried by the air flow. The drying component 112 can have any other suitable configuration.
[0092] The over spray nozzle 115 can have a number of different configurations. Regardless of your specific configuration and shape, the over spray nozzle 115 inside the housing is configured to collect any over spray. After a sanitization cycle, an air flow can be directed through the surface of the over-spray collector 115 to cause evaporation. In some embodiments, in addition or alternatively, the amount of excess spray can be collected into a drain or other receptacle for removal from the device and disposal.
[0093] Systems 200, 200 ', 200 in Figure 2A, Figure 2B, and Figure 2C, respectively, illustrate more detailed examples of system 100 shown in Figure 1. As shown in Figure 2A, system 100 includes a housing 202 o which may be similar to housing 102 of Figure 1. As shown, housing 202 includes, among other components, an air tank 204, an air pump 214, an active agent receptacle 206, a fluid pump 228, a competition 870180001867, from 01/09/2018, p. 10/23
21/64 nozzle component 208 that has one or more nozzles, a sensor module 210 that has one or more sensors configured to detect a target surface in the vicinity of nozzle component 208, an optional drying component 238, a optional overspray 240, and a controller 212 operatively coupled to a display 213. In this example, the target surface is shown in the form of a hand 207 being sprayed with an active agent 209, although it should be appreciated that any other surface can be sanitized using system 200. Air tank 204 and active agent receptacle 206 are used to supply air and an active agent, respectively, to nozzle component 208 so that the active agent is delivered to a surface- target as an aerosol that is deposited on the surface as a thin layer. The aerosol can be generated in many suitable ways. The system 200 can be an airflow-based atomization spray system, an ultrasound spray system, or another type of an atomization system (for example, a pressure-based atomization spray system, etc.).
[0094] In the system described, the air pump 214, the air tank 204, the active agent receptacle 206, the nozzle module 208, as well as other components of housing 202, are controlled via controller 212. The display 213 it is communicatively coupled to controller 212 and is configured to display information regarding the operation of the system in any suitable way. Display 213 can be an interactive display configured to receive instructions for operating the system. Controller 212 can be implemented in hardware, software, or a combination thereof.
[0095] The air tank 204 has a pressure sensor 205 associated with it that is configured to monitor the pressure inside the tank 204. As shown in Figure 2A, the air tank 204 is
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22/64 coupled to air pump 214 which is controlled to draw in ambient air and supply it to air tank 204. A communication line between air pump 214 and air tank 204 can be equipped with a flow meter. pressure 211 as shown in Figure 2A. The air sucked in by the air pump 214 can be passed through an air filter 216. The air is provided with an outlet 218 from the air tank 204 to the nozzle component 208 through a duct 220. As shown, the air can be passed through a filter 222 and its supply to the nozzle component 208 is controlled via a control valve 224. A pressure regulator component 226 controls the pressure of the air passed through the duct 220. The operation of the pressure pump air 214 maintains the pressure inside the air tank 204, under control by controller 212.
[0096] Active agent receptacle 206 is in fluid communication with fluid pump 228 which provides a dosage of active agent from receptacle 206 to nozzle component 208. Controller 212 controls the volume and delivery time of a dose . The dosage can be preset so that one or more nozzles of the nozzle component 208 provide a predetermined amount of the active agent each time the nozzles are activated. In some embodiments, however, the dosage can be determined by the controller 212 dynamically, based on the size and other properties of the target object to be sanitized. Object properties can be determined using sensor component 210 or in other modes. For example, display 213 or another system component can be interactive, and can be used to receive a user input for the surface being cleaned, including an entry to activate system 200. For example, in some embodiments, two or more options can be provided so that the user can select (for example, pressing a button or fl
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23/64 using one hand over the button) if one hand, both hands, or any other surface can be cleaned. Furthermore, similar to system 100 in Figure 1, system 200 can receive instructions through a suitable mechanism such as a button, touch screen, pedal, or other control mechanism configured to activate the system. The control mechanism can be attached to housing 102 (for example, it can be attached to the housing or attached to it via a wired connection) or it can be a remote device that communicates wirelessly with the housing components.
[0097] As shown in Figure 2A, the active agent receptacle 206 may have a filter 230 associated with it that filters dirt and other impurities from the ventilation air that displaces the active agent and the agent is removed from receptacle 206. The filter can be removable and replaceable.
[0098] Housing 202 may include a power supply module 232 that can draw power from a battery element 234 or an AC power supply through an AC outlet 236. The battery element can be removable and replaceable. In some implementations, system 200 may be portable.
[0099] The one or more nozzles of the nozzle component 208 can have a variety of different configurations, and these can be stationary or mobile. In some implementations, the system may have both stationary and movable nozzles so that one or more of the nozzles are stationary, while one or more of the nozzles are movable. The nozzles can be arranged in various modes in order to provide an active agent in a desired mode. For example, nozzles may be arranged at certain locations on a system housing in a manner that requires moving a hand with respect to the nozzles to ensure complete coverage of the hand with the active agent. In some instances, however, nozzles may be
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24/64 are arranged so that a hand can simply be positioned in its proximity and no additional hand movement is required to adequately cover the hand with the active agent provided by the nozzles. In such examples, at least a portion of the housing can be formed so that one or more hands can be positioned to be treated with an active agent and no additional hand movements can be required for treatment. This helps to ensure compliance. For example, the housing may have a cavity or other opening that has nozzle openings on its inner walls. The cavity can be of any suitable shape and size. As an example, the cavity can be formed to conform to the shape of the hand or otherwise allow coverage of the hand without additional user actions after the hand has been placed inside the cavity. However, it must be appreciated that the cavity can be oval, rectangular, or it can have any other shape. The size of the cavity can allow it to receive one or two hands. Furthermore, in some implementations, more than one person can use the system to sanitize their hands simultaneously. The nozzles can be of various sizes and shapes in order to provide an aerosol of active agent in a desired mode.
[00100] Figures 3, 4, and 5A-5C illustrate examples of different types of nozzles that can be used in conjunction with system 200 or another system that implements the techniques described, for example, system 200 '(Figure 2B) and system 200 (Figure 2C) described in more detail below. Figure 3 shows an example of a portion of a system 300 that implements the described techniques. As shown, system 300 includes a housing 302 that has a single stationary nozzle 304 configured to provide an active agent for a surface such as, in this example, a hand 306. It should be appreciated that although a user's hand 306 is shown,
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25/84 Depending on the size and configuration of the stationary nozzle 304, the nozzle 304 can provide an active agent to sanitize both the user's hands at the same time.
[00101] Figure 3 shows the user's hand 306 placed adjacent to the stationary nozzle 304 so that the palm side of the hand faces the nozzle 304. In this configuration, the active agent is delivered from the nozzle 304 and delivered to the palm side of hand. In order to receive the active agent on the top of the hand, the user needs to rotate his hand 180 degrees so that the top of the hand faces the nozzle 304. In this configuration, the cone angle of the sprayed active agent can be designed to allow delivery to the sides of the hand and the sides of the fingers. To ensure that these regions of the hand are not blocked (for example, because the user has closed or folded the fingers, sawed the hands, or the hands are touching each other), the system 300 can provide an indication to the user informing the user of the requirement to keep your hand in an appropriate manner. For example, an indication can be provided to the user in an audio, visual, or a combination reminding the user to position their hand so that the fingers are open, the hands are not in contact with each other or others objects, etc. In addition, since a person is more likely to have their fingers open if the palm of their hand is facing up or down (rather than laterally, as during a handshake position), the system can be configured so that he can receive a hand only if it is arranged with the palm facing up or down.
[00102] Figure 4 shows a portion of a system 400 that implements the techniques described with the nozzles and I try another configuration. System 400 can have the same or similar components as those described in connection with systems 100 (Figure 1), 200
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26/64 (Figure 2A), 200 '(Figure 2B), and 200 (Figure 2C). In this example, the system 400 includes a housing two portions of which are shown as upper and lower housing portions 402a, 402b. As shown, the upper and lower housing portions 402a, 402b have nozzle networks 404a, 404b associated with them, respectively. It should be appreciated that, although in system 400 each of the nozzle networks 404a, 404b has three nozzles, the nozzle networks can have any suitable number of nozzles (for example, two or more than three), including a different one number of nozzles between nets.
[00103] In the example in Figure 4, as shown, nozzle networks 404a, 404b can provide an active agent to both sides of a target surface, such as the tops and bottoms of a pair of hands 406. A knowledgeable person in the art you will appreciate that any other surface that has an appropriate shape and size can also be cleaned using the 400 system.
[00104] Nozzle networks 404a, 404b can have a variety of different configurations. In Figure 4, each of the networks is a linear network that has the nozzles arranged along the same line. It should be appreciated, however, that in one or both networks the nozzles can form rectangular, circular, oval, elliptical, or other patterns.
[00105] In one embodiment, the nozzle network can be a linear strip with a micro hole formed as a slit along the length of the strip. The linear strip can be standardized as a serpentine layout to allow uniform delivery of micro droplets of an active agent through an area under (or above) the serpentine layout, to the hands.
[00106] Furthermore, in some modalities, the nozzles can be arranged and directed to a location where a surface
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The target 27/64 must be placed so as to form several patterns that may not necessarily be referred to as networks. For example, as discussed above, a housing can have a cavity or other structure that has a contour in the shape of a hand, and multiple nozzles can be arranged so that their holes are arranged along the inner walls of such a cavity. The cavity can have an opening for a hand to be inserted into it. In such a configuration, a hand disposed within the cavity need not be turned or otherwise moved to be adequately covered with an active agent emitted from the nozzles which is then dried. The cavity can be formed so that a hand can be inserted into it with the palm facing up or down, in a position which would be appropriate for a handshake, or in another way. The cavity can also be designed so that both a user's hands can be cleaned at the same time. The cavity is positioned so that it can receive the hand (s) in a convenient mode for a user. Regardless of the configuration and position of the cavity and nozzles, the system can be configured to adequately sanitize at least one grip surface of the hand (s).
[00107] Figures 5A-5C schematically illustrate a mobile network of nozzles 502 (used with a sanitizing system, not shown) that are configured to provide an active agent for a pair of hands 506 to perform hand sanitization. Unlike a stationary nozzle arrangement, the mobile net moves over a surface of the hands (or any other object) during the cleaning process. In the illustrated example, the nozzle network 502 is shown as a linear strip, although, as a person skilled in the art will appreciate, other configurations can be used alternatively. Figure 5A shows a position of the bo
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28/64 pier 502 in a first period of time, at the beginning of the hand hygiene process when net 502 is arranged around the wrists of the hands. Figure 5B illustrates a position of the nozzle net 502 in one second, an intermediate period of time for the sanitization process when the nozzle net 502 moved halfway with respect to the user's hands 506. Finally, Figure 5C illustrates a position of the nozzle net 502 in a third, later time period where nozzle net 502 passed over the user's hands 506. In the example shown in Figures 5A-5C, hands can be placed above or below net 502 so that the network can scan above and below the pair of hands, thereby providing an active agent for the tops and bottoms of the hands, where the method of delivering the active agent and drying the hands can take less than 5 seconds.
[00108] In Figures 3, 4, and 5A-5C, the nozzles of the respective systems are arranged so that the hand or hands are oriented with the sides of the palm facing up or down, and where the normal to the palms are aligned with the gravity direction. In other modalities, the system can be configured so that the hands can be oriented with palms turned by 90 degrees or facing the side as is conveniently achieved when shaking hands with another person.
[00109] One or more nozzles of a system that implements the described techniques can operate in several different modes. Thus, regardless of the specific configuration and layout, the nozzles can be operated using an airflow, pressure, ultrasonic, or other techniques. The nozzles may have orifices of different sizes and configurations that can allow an active agent such as a spray to be expelled that has desired distribution patterns. For example, in some cases,
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29/64 may provide a circular distribution of the sprayed agent on a target surface. In other cases, in addition or alternatively, the nozzles may produce a fan-shaped spray pattern relative to a stationary target object. The nozzles can be equipped with several components (for example, air layers) that allow to generate a spray that has desired characteristics.
[00110] The nozzles can have several operating parameters. Thus, nozzles can operate at a certain air pressure to provide an appropriate active agent flow rate to create a thin, uniform layer of active agent on a target surface in a relatively short period of time (for example, less than five seconds, less than three seconds, or less than one second). The uniform thin layer is then dried on the targeted surface so that the total time required to hand wash is less than five seconds, less than three seconds, or less than one second. For example, in one embodiment, an ultrasonic nozzle can operate at an air pressure ranging from approximately 1.38 kPa (0.13.8 Kpa (2 psi)) to approximately 34.5 Kpa (5 psi). The active agent can be expelled from such a nozzle at a flow rate of approximately 15 mL / min to achieve a coating thickness of approximately 10.0 pm in a 1 second over a surface area equivalent to the side of a hand, when supplied with air at approximately 13.8 Kpa (2 psi) air pressure. In another embodiment, an air atomizing nozzle can have an active agent flow rate of approximately 35 mL / min, operating at a rate of 82.8 Kpa (12 psi) for air atomization and 69 Kpa (10 psi) for the active agent. A surface on one side of a hand can be coated using such a nozzle to a thickness of approximately 10.0 pm in less than 0.5 seconds. Air atomizing nozzles of this type can be operated under an air pressure that varies from
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30/64 approximately 34.5 Kpa (5 psi) to approximately 690 Kpa (100 psi), with the liquid supplied over a range of approximately 69
Kpa (10 psi) at approximately 345 Kpa (50 psi).
[00111] Referring back to Figure 2A, as mentioned above, housing 202 may also include an optional drying component 238 configured to dry target surface 207 after active agent 209 in the form of an aerosol is delivered over the target surface 207 In this example, the drying component 238 can be an air dryer that can provide an air flow to dry a target surface after it has been treated with the active agent. The drying component 238 can have a variety of configurations. The drying component 238 can use a flow of ambient air that has room temperature or the air can be heated. Alternatively, the drying component can be an infrared heater that can provide infrared radiation to the target surface to dry it. The drying component can have any other configurations, since the techniques described are not limited in this respect. Regardless of its specific configuration, the drying component, if present, is configured to dry the thin film of an active agent deposited on a target surface.
[00112] As described above, the drying component can be controlled to dry a target surface for a predetermined period of time. The time period can be preset so that the drying process continues for a predetermined length of time, for example, five seconds, three seconds, or another duration. As another option, the level of drying required may depend on the user's actions. In such scenarios, drying can proceed until the system determines that the user's hand (or other surface) being sanitized is no longer in the vicinity of the sensor. In some embodiments, sensor 210 or one or more other senses
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31/64 res that can alternatively or in addition be associated with the system can detect the level of drying of the target surface.
[00113] The sensor module 210 can also have a variety of different configurations, and it can have one or more sensors of any suitable type. The sensor of the sensor module 210 may be an optical proximity sensor that is capable of detecting the target object shown by way of example only as the hand 207 in Figure 2A. The optical proximity sensor may also be able to detect a position and movement of the hand 207 or another target object. For example, the sensor can detect that hand 207 has been arranged in the vicinity of nozzle (s) 208, and it can also detect a mode in which hand 207 is positioned with respect to nozzle (s) 208 Other events can also be detected by one or more sensors from sensor module 210, as described below.
[00114] The active agent receptacle 206 of the system 200 can have various configurations and it can receive and store the active agent in a variety of modes. Thus, the active agent receptacle 206 may be configured as a refillable reservoir that is configured to receive a supply of the active agent. When the amount of the active agent is below a certain amount, an appropriate indication can be provided. In some embodiments, the active agent receptacle 206 houses a cartridge that contains removable and refillable active agent. The cartridge can be replaceable so that it is preloaded with an active agent.
[00115] It should be appreciated that system 200 in Figure 2A is described as an example only, since systems that have other configurations can implement the techniques described. Thus, another example of a system in which the described techniques can be implemented is shown in Figure 2B where a system 200 'is configured to provide an active agent 209' in the form of a spray
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Aerosol 32/64 to a surface 207 '(for example, an unprotected or gloved hand). As shown, system 200 'includes a housing 202' that has a controller 212 'associated with a display 213', an active agent receptacle 206 ', a fluid pump 228', a nozzle component 208 'that has one or more more nozzles, a sensor module 210 '(other ways to activate the system 200' can be used in addition or alternatively), a drying component 238 ', a power supply module 232' that can draw energy from an element of battery 234 'or an AC power supply through an AC outlet 236', and an optional over-spray collector 240 '. These components can be similar to the corresponding components of system 200 (Figure 2A) and therefore are not described in more detail. The 200 'system may not include air supply components. However, in some implementations, one or more air supply components may be present. In this example, the atomized active agent can be moved from the nozzle (s) of the nozzle component 208 'to the target surface 207' by at least one fan (optional) 219 '. The 200 'system can be an ultrasonic atomization system. Furthermore, the system configuration 200 'can also be representative of a pressure-based atomization spray system.
[00116] Yet another example of a system in which the described techniques can be implemented is shown in Figure 2C where a system 200 is configured to deliver an active agent 209 in the form of an aerosol spray to a surface 207 (for example, a unprotected or gloved hand). As shown, system 200 includes a housing 202 that has a filter 216, a pump 214, a sensor 205, a meter 211, an air tank 204 with an outlet 218, a filter 222, a pressure regulator component 226, a control valve 224, a controller 212 as
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33/64 associated with a display 213, a filter 230, an active agent receptacle 206, a nozzle component 208 that has one or more nozzles, a sensor module 210 (other ways to activate system 200 can be used in addition or alternatively), a drying component 238, a power supply module 232 that can draw power from a battery element 234 or an AC power supply through an AC outlet 236, and an optional overspray collector 240 The air is provided from the outlet 218 of the air tank 204 to the nozzle component 208 through a duct 220. These components can be similar to the corresponding components of the system 200 (Figure 2A) and therefore are not described in more detail in connection with Figure 2C. In this example, the active agent is displaced from the active agent receptacle 206 by air from the air tank 204. A control valve 229 under control of the controller 212 admits the pressurizing air to receptacle 206. The fluid supply from receptacle 206 to the nozzle component 208 occurs when the control valve 231 is actuated by the controller 212.
[00117] It should be appreciated that systems 100 (Figure 1), 200 (Figure 2A), 200 '(Figure 2B), 200 (Figure 2C) are exemplary only, and that systems 100, 200, 200', 200 can include other components that are not shown here.
[00118] Regardless of the specific configuration of the system that implements the described techniques, the techniques provide a method to exterminate or inactivate transient pathogens on a skin surface or any other surface. Figure 6 illustrates a process 600 of exterminating or inactivating transient pathogens on a surface using an active agent that includes one or more antiseptic or disinfectant reagents, according to the techniques described. Process 600 is described here in connection with system 200 (FiguPetição 870180001867, from 01/09/2018, page 36/105
34/64 ra 2A) as an exemplary system which can perform this process. However, it should be appreciated that process 600 can be performed by system 100 (Figure 1), system 200 '(Figure 2B), system
200 (Figure 2C), or by any other suitable system.
[00119] Process 600 can start at any appropriate time. For example, it can start when a system that runs it (for example, system 100 or 200) is activated. Process 600 can be controlled by a system control module, such as, for example, controller 212 in Figure 2.
[00120] In block 602, the system can monitor by the presence of a target surface in the vicinity of the nozzle (s) of the system (for example, nozzle module 208 in Figure 2A). The target surface is considered to be in the vicinity of the nozzles when it is adjacent to the nozzles so that an active agent that can be supplied from the nozzles can reach the surface to adequately cover it with a layer of the active agent. The target surface can be one or both of the user's hands, or another object. The user's hand or hands may be bare or gloved. As discussed above, a proximity sensor, a motion sensor, or another type of sensor can operate to determine whether a surface is detected in its vicinity.
[00121] Also, in some modalities, the system can be activated to perform the surface cleaning process in other modes, which may be different from the processing in blocks 602 and 604 in Figure 6, which are shown as an example only. Thus, in addition or alternatively, the system can receive an instruction from a user through a suitable mechanism such as a pedal, button, touch screen, sensor, or any other control mechanism configured to activate the system. The control mechanism can be coupled to a system housing
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35/64 (for example, it can be attached to the housing or attached to it via a wired connection) or it can be a remote device that communicates wirelessly with components of the housing. Thus, in some embodiments, the target surface may not be detected but instead the system is activated to perform the techniques described in response to another suitable trigger.
[00122] Regardless of the specific mode in which the target surface is determined to be in close proximity to the nozzles and / or the way in which an instruction to activate the system is received, in response to determining that the target surface is adjacent to the nozzle , process 600 continues to block 606 where the active agent is delivered over the target surface. The active agent can include an ingredient that can exterminate or inactivate a transient pathogen on the surface, or a mixture of two or more such ingredients, examples of which are discussed below. The active agent is delivered from one or more nozzles, such as the nozzle (s) of the nozzle module 208 shown in Figure 2. The active agent is delivered over the surface in the form of an aerosol spray, and forms an aerosolized layer that is a thin and substantially uniform coating on the target surface.
[00123] The active agent layer can be from approximately 1 pm to approximately 50 pm in thickness. Furthermore, in some embodiments, the active agent layer can be from approximately 5 pm to approximately 20 pm in thickness. In still other embodiments, the thickness of the active agent layer can be from approximately 4 pm to approximately 10 pm.
[00124] The system can be configured to supply the active agent so that there are no uncoated areas on the surface (or so that the uncoated areas do not affect the result of the cleaning process). Uniform coating can be achieved due to the aerosol properties of the active agent. Specifically,
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36/64 the active agent in the form of an aerosol includes small droplets of fluid that have a size (or a size distribution) that allows a uniform thin layer of the active agent to be formed on a target surface. In at least some embodiments, the droplets of active agent can be from approximately 18 pm to approximately 56 pm in diameter. The droplet size distribution can vary in different ways and an average droplet diameter can be approximately 33 pm in diameter. In at least some embodiments, droplet sizes can be from approximately 36 pm to approximately 107 pm with an average diameter of approximately 57 pm. In other embodiments, droplet sizes can vary from approximately 28 pm to approximately 116 pm, with an average diameter of approximately 59 pm. It should be appreciated that droplets of active agent of other sizes can be formed in addition or alternatively. The active agent delivery process in block 606 can be controlled to ensure proper treatment of the target surface. For example, one or more suitable sensors (for example, sensor 210 and / or any other sensor) can monitor the agent delivery process to ensure adequate surface coverage. The sensors can determine whether any fluid is present on the target surface, as a way of controlling the appropriate delivery of the active agent over the surface. The sensor (s) can also monitor the degree of uniformity of the deposition of active agent on the target surface.
[00125] If it is determined, in decision block 604, that the target surface has not been detected, process 600 can return to block 602 to continue monitoring for the presence of the target surface, as shown in Figure 6.
[00126] After the active agent has been delivered over the surface
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37/64 cie, the active agent is dried on the surface, in block 608. Drying can be carried out by a suitable drying component such as, for example, drying component 238 (Figure 2A). The drying can be carried out by an air flow (which can be cold or hot air), by an infrared dryer, or using any other proposal. As mentioned above, the drying component is optional, and the active agent layer provided on the target surface can be dried by room air. For example, the user can simply wait for a few seconds for their hands treated with an active agent to dry.
[00127] The processing steps in blocks 606 and 608 can both be completed quickly, for example, in less than five seconds. The delivery of the active agent can take less than three seconds, and drying the agent arranged as a layer on the treated surface can take less than two seconds. However, the agent supply and drying steps can be performed over other periods of time. Furthermore, in some modalities, the entire process of treating a target surface can take less than three seconds. In this way, the user can have their hands sanitized in a convenient and timely manner.
[00128] Regardless of how the drying is performed, in block 610 of Figure 6, the system can determine if the drying is complete and provide an indication of completely the drying step. A suitable optical sensor can monitor the target surface being treated and it can determine when the surface is considered to be sufficiently dry. For example, the sensor can be used to automatically determine if there are any wet areas present on the surface and determine a level of surface drying. The indication can be provided to the user in the form of audio, visual, or others. For example, an audio signal can
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38/64 be generated to indicate to the user that their hands have been cleaned. As another option, in addition or alternatively, a visual indication (for example, a light indicator, textual message, or other indication) can be presented to a user on a display, such as, for example, display 213 in Figure 2A. In addition, a suitable indication can be provided to a user during the application of active agent and / or active drying. For example, a color indicator can be provided while the process is in progress, and the color can change once the process is completed. Also, in some modalities, no indication of complete drying is provided and the user can notice that their hands are dry.
[00129] Regardless of the way in which drying is carried out, the active agent on the surface of the hands is effective to exterminate or inactivate the transient pathogens on this surface. Furthermore, due to the way in which the active agent is delivered over the hands, the active agent can cleanse the skin without significantly affecting the skin's resident microflora. In addition, even if the active agent belongs to a class of strong disinfectants that would otherwise be considered aggressive to the skin (those that are nevertheless desired for use in certain environments), the rapid application of a thin layer of the agent active using the techniques described allows to reduce the negative effects of such strong disinfectants.
[00130] After the completion of drying indication is provided, process 600 may terminate. It should be appreciated, however, that process 600 can be continuous. In this mode, after a surface has been treated, the system monitors for the presence of another surface in the vicinity of the nozzles, and / or waits for a trigger to start delivering the active agent. For example, in a
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39/64 hospital, a device that executes the process 600 can, in rapid sequence, clean the hands of multiple employees.
[00131] Figure 7 illustrates another example of a process of exterminating or inactivating transient pathogens on a surface according to the techniques described. Process 700 shown in Figure 7 is similar to process 600 in Figure 6 and can similarly be performed by a system such as system 100 (Figure 1), system 200 (Figure 2A), system 200 '(Figure 2B), system 200 ( Figure 2C), or by any other suitable system. Process 700 is described here as an example only as being performed by system 200 of Figure 2A. Also, process steps 700 that are similar to the corresponding process steps 600 are not described in detail in connection with Figure 7.
[00132] As shown in Figure 7, after process 700 starts at an appropriate time, the presence of a target surface can be detected in block 702. As discussed above, the target surface can be detected by one or more sensors ( s), or the system that performs the current process can respond to a suitable trigger, such as an instruction to activate the nozzle. In some implementations, the sensors used may be able to determine one or more properties of the detected surface, such as its size and contours.
[00133] When the target surface is detected, in block 704, an air flow with regulated pressure is provided for the nozzle. For example, as shown in the example in Figure 2A, air from the air tank 204 can be made, by the air pump 214, to be supplied to the nozzle component 208. This process is controlled by a control module (for example, controller 212 in Figure 2A). Air can be supplied to a nozzle module at a desired air flow pressure. The air flow pressure is selected so that it is sufficient
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40/64 high to quickly cover a surface being treated, but at the same time not excessively high, as high pressure can generate an aerosol flow that is deposited as a layer which is thicker than desired. In modalities in which an ultrasound atomizer is used to generate the aerosol, a lower pressure can be used, for example, from approximately 3.45 Kpa (0.5 psi) to approximately 34.5 Kpa (5 psi). In other embodiments in which an airflow-based atomization spray system is used, a higher pressure can be used, for example, greater than approximately 34.5 Kpa (5 psi).
[00134] In block 706, as shown in Figure 7, at least one nozzle of the system that performs the process is activated. A dosage of the active agent can be provided for the activated nozzle in block 708. Referring again as an example only to system 200 in Figure 2A, the active agent can be provided, by the fluid pump 228, of the active agent receptacle 206, for the nozzle component 208.
[00135] The dosage can be selected based on the expected surface of the target surface to be cleaned, which can be done in advance (for example, if the nozzles are used to spray surfaces of similar sizes) or the dosage can be selected dynamically, based on properties (for example, size, contours, etc.) of the specific target surface being treated. For example, in modalities where the system is configured to disinfect hands, the dosage can be selected based on the size of the area of one or both hands. In the case of an individual hand, where the surface area is approximately 500 cm ² , a supplied dose of 0.5 mL of an active agent uniformly distributed across this hand surface would generate a coating approximately 10 pm thick. A 3 mL dose of active agent
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41/64 supplied uniformly across the same surface area would generate a coating approximately 60 pm thick. Allowing about 30% of excess spray (excess of active agent that spreads beyond the target surface being sprayed), the dosage of 3 ml can be increased to approximately 4 ml to generate a coating of 60 pm thick. The uniform coating of two hands with a coating of 60 pm thick and 30% excess spray would require a dosage of approximately 8 mL. In cases where only the palms and surfaces of adjacent fingers of a pair of hands are treated, 30% excess spray is expected and the coating thickness is approximately 10 pm in thickness, the dosage of the active agent can be approximately 1.5 ml.
[00136] In block 710, the dosage of the active agent is supplied from the nozzle so as to form a thin uniform layer on the targeted surface. As discussed above, the active agent is provided in the form of an aerosol spray. The aerosol spray can be created by an air atomizing nozzle that uses air pressure to create the spray, as well as to deliver the spray droplets to the target surface. In other embodiments, the system may be an ultrasonic nozzle system. In still other embodiments, the system can use hydraulic nozzles. A positive displacement pump, a suction or pressure based fluid supply proposal, or any other suitable proposal can be used to supply the fluid to the nozzle or nozzles. As an example, in system 200 of Figure 2A, the aerosol is created by aerosolizing the active agent received from the active agent receptacle 206 in the air flow supplied to the nozzle through conduit 220.
[00137] After the target surface is sprayed with the desired dosage of the aerosolized active agent, a drying component is
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42/64 activated to dry the active agent on the surface, in block 712.
An indication of completion of the drying process, and therefore completion of surface cleaning, is provided in the block
714. Process 700 can then end, although it can be performed continuously, to sanitize another target surface.
[00138] The active agent can include one or more ingredients that can be used to inactivate or exterminate transient pathogens on a target surface such as a hand surface. Any one or more pathogen inactivating fluid or germicidal fluid can be used in the active agent. The active agent is selected so that it can be delivered over a target surface as a thin, uniform, quick-drying coating capable of quickly exterminating or inactivating transient pathogens on the target surface.
[00139] As an example, the active agent can be an aqueous solution of hypochlorous acid. Any suitable source of hypochloride can be used. For example, Excelyte (Integrated Environmental Technologies, LTD., Little River, SC) or another suitable source of hypochlorous acid can be used. Excelyte can be given as a possible aqueous composition of hypochlorous acid, as it is reported (according to the packaging label) to be effective in exterminating Clostridium difficile, Escherichia coli, MRSA, Salmonella, Pseudomonas, Listeria monocytogenes, Enterococcus faecalis (VRE ), Klebsiella pneumonia (NDM-1) and Staphylococcus aureus. The aqueous solution of hypochlorous acid can have any suitable concentration of hypochlorous acid. In some embodiments, the aqueous hypochlorous acid solution includes at least approximately 0.046% hypochlorous acid. As another example, the aqueous hypochlorous acid solution may include from approximately 0.005% to approximately 1% hypochlorous acid. A suitable commercial product or solution can be used as an active agent.
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43/84 [00140] As another example, the active agent can be an aqueous solution of hydrogen peroxide used as a pathogen or germicidal inactivation fluid, since hydrogen peroxide is a broad antimicrobial spectrum capable of inactivating or killing bacteria , viruses, fungi and spores. The aqueous solution of hydrogen peroxide may include approximately 0.3%, approximately 1%, approximately 3%, approximately 6%, approximately 9% or approximately 12% hydrogen peroxide. In some embodiments, the aqueous solution of hydrogen peroxide can be used with a concentration of hydrogen peroxide in the range of approximately 3% to approximately 6%.
[00141] As another example, the active agent can be accelerated hydrogen peroxide or ΑΗΡ. AHP is a proprietary blend of hydrogen peroxide, surface active agents, wetting agents, chelating agents and water designed for improved germicidal potency and cleaning performance (Virox, Oakville, ON, Canada). AHP is used as a pathogen or germicidal inactivation fluid since it is a broad spectrum antimicrobial capable of inactivating or exterminating bacteria, viruses, fungi and spores and is expected to promptly wet the surfaces of the hands, allowing the development of a coating thin, uniform spray of controlled AHP micro droplets over your hands. When the active agent is an aqueous solution of hydrogen peroxide, the aqueous solution of hydrogen peroxide can be used with a concentration of hydrogen peroxide in the range of approximately 3.0% to approximately 12.0%.
[00142] As another example, the active agent can be an aqueous solution that is a mixture of peracetic acid and hydrogen peroxide.
[00143] As yet another example, the active agent can be a
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44/64 aqueous acetic acid solution. The aqueous solution can have a concentration of acetic acid in the range of approximately 1% to approximately 10.0%. In other embodiments, the aqueous acetic acid solution used can have a concentration of acetic acid in the range of approximately 3.0% to approximately 6.0%. An aqueous solution of acetic acid is used as a pathogen or germicidal inactivation fluid when broad-spectrum bacterial inactivation or extermination is desired.
[00144] In some embodiments, the active agent may include an aqueous solution of isopropyl alcohol. The aqueous solution of isopropyl alcohol can have an isopropyl alcohol concentration of approximately 60% to approximately 90%.
[00145] In some embodiments, the active agent may include an aqueous solution of ethanol. The aqueous ethanol solution can have an ethanol concentration of approximately 60% to approximately 90%.
[00146] And another embodiment, the active agent can include an aqueous solution of peracetic acid. The aqueous peracetic acid solution can have a concentration of peracetic acid from approximately 0.1% to approximately 1.0%.
[00147] In another embodiment, the active agent may include an aqueous solution of sodium hypochlorite. The aqueous sodium hypochlorite solution can have a sodium hypochlorite concentration of approximately 0.1% to approximately 1.0%.
[00148] Regardless of the specific ingredient or a mixture of ingredients included in the active agent, the process of spraying a small volume of the active agent, followed by a quick drying of the hands, has the effect of reducing the numbers of viable transient bacteria on the surfaces of the hands. This thin, uniform coating of fluid is quickly dried by exposure to the environment or
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45/64 using active techniques such as, for example, forced air flow, forced heated air, or infrared radiation. The act of drying to or substantially reduces the process of inactivating the extermination of pathogen thereby limiting the microbial inactivation or extermination of the transient pathogens on the outermost surface of the skin. The cleansing process has the effect of inactivating or exterminating transient pathogens on the surfaces of the hands, which can be done without substantially altering the resident microflora population or causing irritation or toxic effects on the skin.
[00149] In at least some embodiments, the active agent can also be an aqueous ozone solution that has an ozone concentration in the range of approximately 1 part per million (ppm) to approximately 40 ppm. In at least some embodiments, ozonized water can have a dissolved ozone concentration of approximately 0.2% to approximately 2.0%. Also, in at least some embodiments, the active agent can also be an aqueous ozone solution that has a dissolved ozone concentration in the range of approximately 0.1 mg / L to approximately 10 mg / L. An aqueous ozone solution can be used as a pathogen or germicidal inactivation fluid since ozone is a broad-spectrum antimicrobial capable of inactivating or killing bacteria, viruses, fungi and spores.
[00150] The active agent can also be a mixture of aqueous solutions of ozone (ie, ozonized water) and hydrogen peroxide. In some embodiments, ozonized water and aqueous hydrogen peroxide can be delivered to the hands as a targeted nozzle surface. These nozzles and spraying protocols can be designed to provide the mixture of ozonized water and aqueous hydrogen peroxide within the spray provided upon impingement over the skin surface. In other modalities
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46/64 des, ozonized water and aqueous hydrogen peroxide can be mixed inside the delivery device before spraying through the same nozzle or nozzle network. Regardless of whether ozonized water and aqueous hydrogen peroxide are supplied together or separately to the target surface, a thin, uniform coating of the active agent supplied over the surface of the hands is quickly dried by exposure to the environment or using active techniques such as, for example, a forced air flow, forced heated air, or infrared radiation.
[00151] The following non-limiting examples describe experiments that were conducted to assess the effectiveness of the techniques described.
[00152] The following examples are presented in order to provide those skilled in the art with examples of how the systems, compositions, devices and / or methods described herein can be made and evaluated, and are intended to be purely exemplary of the present description and are not intended to limit the scope of the description. Thus, the examples below are merely illustrative of techniques for cleaning hands or other surfaces in various environments.
EXAMPLES
Example 1 [00153] This example describes the inactivation of bacteria on human hands by a brief spray of pathogen inactivation fluid followed by rapid drying.
[00154] An original solution of the Escherichia coli K-12 strain was obtained (Carolina Biological Supply Company, Burlington, NC) and diluted 10,000 times in a nutrient broth (Carolina Biological Supply Company, Burlington, NC) to generate a bacterial solution diluted. In this example, 25 pL of diluted solution was pipetted over the tips of the index, middle and ring fingers of a human hand.
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47/64
After pipetting, the solutions were spread with a pipette tip and allowed to dry under a small fan (Delta model BFB0712HH-A, Digi-Key, Thief River Falls, MN) for a few minutes. It is estimated that this 25 μΙ_ solution contained between 70 and 100 bacteria, based on plaque counts from this same batch of solutions, described in Example 4 below. Right after drying, an aqueous solution of hydrogen peroxide (3.0% concentration) was sprayed for 1 second over the middle and ring fingers of the index, middle and ring fingers previously treated with Escherichia coli. The spraying apparatus included an air brush (Patriot Model 105, Badger, Franklin Park, IL) that is capable of spraying thin coatings of a wide variety of fluids with viscosities similar to water. The index finger also previously treated with the diluted solution of Escherichia coli was not sprayed with the aqueous solution of hydrogen peroxide. After spraying the hydrogen peroxide solution, the middle and ring finger tips were dried under the same small fan for 5 seconds. All three fingertips were then pressed onto a pre-melted Luria broth (LB) agar plate (Carolina Biological Supply Company, Burlington, NC). Figure 8 shows this agar plate after an overnight incubation at 37Ό. This plate shows at least 5 bacterial colonies that grew on the region (803) of the agar that was contacted with the non-sprayed index finger tip. No bacterial colony was seen to have grown on the regions of the agar plate that were contacted with the middle (801) and annular (802) fingertips that were quickly sprayed with a pathogen inactivation and extermination fluid and dried with a small volume forced air.
Example 2 [00155] This example describes the inactivation of bacteria on
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48/64 human hands from a brief spray of pathogen inactivation fluid followed by rapid drying.
[00156] A solution of the Escherichia coli K-12 strain was obtained and diluted 10,000 times in a nutrient broth to generate a diluted bacterial solution. All biological supplies were supplied from the Carolina Biological Supply Company (Burlington, NC). In this example, 5 μΙ_ of this diluted solution was pipetted over the tips of the index, middle and ring fingers of a human hand. After pipetting, the solutions were spread with a pipette tip and allowed to dry for a few minutes under the small fan as described in Example 1. It is estimated that this 5 μΙ_ solution contained between 15 and 20 bacteria, based on plate counts of this same batch of solutions, described in Example 4. Shortly after drying, an aqueous solution of hydrogen peroxide (3.0% concentration) was sprayed for 1 second over the middle and ring fingers of the index fingers , medium and annular previously treated with Escherichia coli. The spraying apparatus was the airbrush described in Example 1. The index finger also previously treated with the diluted solution of Escherichia coli was not sprayed. After spraying the hydrogen peroxide solution, the middle and ring finger tips were completely dried under the same small fan for 5 seconds. All three fingertips were then pressed onto a pre-melted Luria broth (LB) agar plate. Figure 9 shows this agar plate after an overnight incubation at 37Ό. This plate shows at least 6 bacterial colonies that grew on the region (901) of the agar that was contacted with the non-sprayed index finger tip. No bacterial colony was seen to have grown on the regions of the agar plate that were contacted with the middle (902) and annular (903) fingertips that were quickly sprayed with a
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49/64 aqueous solution of hydrogen peroxide and dried with a small volume of forced air.
Example 3 [00157] This example describes testing to determine the amount of water deposited as an atomization spray system based on airflow and dried with a small fan.
[00158] The amount of water deposited from an air brush and the amount of drying that takes place within 5 seconds of exposure to the air flow of a small fan were evaluated on a 25 mm diameter polycarbonate membrane engraved on a 0-pore track , 4 pm diameter (Whatman Cyclopore Model 7060-2504, Sigma-Aldrich, St. Louis, MO). The air brush and small fan used in this example are described in Example 1. The initial weight of the membrane was measured using a precision scale (Sartorius Model CPA64, Bohemia, NY). After initial weighing, the membrane was placed on a polycarbonate support block and retained by the weight of a polycarbonate plate, which contains three hollow holes of 16.3 mm in diameter. The plate was placed so that one of the holes was concentric with the membrane. The membrane was then finely coated with water through the hole in the retaining plate, using the Badger spray brush for approximately 1 second. The plate was immediately removed to allow the membrane to be placed on the weighing scale. After the reading was obtained, the membrane was placed in a different location on the support block and fastened again with the retaining plate, but aligned with a different hollow hole. This was done to prevent any water remaining on the retaining plate or support block from running over the test disc. The small fan was then kept a few inches above the membrane with an air flow of approximately 0.43 m ³ / min (15.3 Cubic Per Minute) (CFM) (from
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50/64 according to the manufacturer's specifications) impinging on the disc for 5 seconds, after which the weight of the membrane was measured again.
[00159] The results are listed in Table 1:
Starting Weight(mg) Weight after spraying (mg) Weight of deposited water (mg) Weight after drying Weight of water removed (mg) 8.5 9.3 0.8 8.5 0.8 8.5 10.3 1.8 8.7 1.6 8.6 10.4 1.8 8.9 1.5 8.6 10.0 1.4 8.4 1.4 8.6 9.5 0.9 8.6 0.9 8.6 9.6 1.0 8.4 1.0 8.6 9.9 1.3 8.6 1.3
[00160] Table 1: Weight measurements to evaluate the amount of water deposited and the amount of water removed after 5 seconds of active drying. The weight after drying was assumed to be at least equal to the initial weight value, for calculating the weight of water removed.
[00161] Based on the spray area and the amount of water deposited on this area, the calculated thickness of the deposited water varies from approximately 3.8 micrometers to approximately 8.6 micrometers. Most of the deposited water can be removed in 5 seconds by drying in a flow of air over the upper surface of the membrane.
Example 4 [00162] This example describes the development of controls for subsequent spraying and drying studies.
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51/64 [00163] A solution of the Escherichia coli K-12 strain was obtained and diluted 10,000 times, 100,000 times and 1,000,000 times in a nutrient broth to produce three diluted bacterial solutions. All biological supplies were supplied from the Carolina Biological Supply Company (Burlington, NC). Three polycarbonate membranes etched into tracks (Whatman Nucleopore, Sigma-Aldrich, St. Louis, MO), each 25 mm in diameter with 0.4 pm pores, were placed under a vacuum collector (Millipore, Bedford, MA ). With the vacuum aspiration operated, 150 pL of one of the diluted bacterial solutions was pipetted over the center of the exposed (matte) surface of each of the polycarbonate membranes. The solution was quickly pulled through the membrane engraved on tracks, leaving the bacteria deposited on the exposed (matte) surface. After 5 minutes of drying over the vacuum collector, the membranes were prepared for the next step in this experiment.
[00164] A first set of controls used the dilution of 10,000 times as the solution as received (original) from Escherichia coli for the deposition stage. For this set of controls, the membranes were placed with the matte side up, on a pre-fused Luria broth agar (LB) plate, directly after bacterial deposition and the drying step on the vacuum collector. The pores of the membrane engraved on tracks allowed the transport of nutrient from the agar to the bacteria deposited on the matte side of the membrane. Figure 10 shows these three membranes on the agar plate after overnight incubation at 37Ό. Figure 10 also shows total circular fields of bacterial colonies in the center of each membrane where the 150 pL of diluted bacterial solution was previously deposited. This experiment establishes that the bacteria can be deposited on polycarbonate membranes, dried and allowed to grow on agar through overnight incubation.
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52/64 [00165] The following experiments involved spraying water over the membranes deposited with bacteria followed by drying with a small fan. For these experiments, spraying was performed for approximately 1 second using an air brush and drying was performed by holding the membrane close to the outlet of the small fan for approximately 5 seconds. The air brush and small fan used for this example are described in Example 1. The spraying action is estimated to have provided a uniform coating, based on the reflective brightness observed at the top of each membrane after each spraying. After 5 seconds of drying with the small fan, the membranes appeared to be free of all fluid and completely dry.
[00166] A second set of controls used the 10,000-fold dilution of the solution as received from Escherichia coli for the deposition step, but instead of directly placing the membranes on an agar plate, the membranes remained on the vacuum collector and they were then sprayed with water, removed, and dried for 5 seconds with forced air from the small fan, before being placed on the agar plate. Figure 11 shows these three membranes on the agar plate after an overnight incubation at 37Ό. Figure 11 also shows total circular fields of bacterial colonies in the center of each membrane where the 150 μΙ_ of diluted bacterial solution was previously deposited.
[00167] A third set of controls used the 100,000-fold dilution of the solution as received from Escherichia coli for the deposition step. After bacterial deposition and drying, the membranes remained on the vacuum collector and were then sprayed with water, removed, and dried for 5 seconds with forced air from the small fan, before being placed on the agar plate. Figure 12 shows these three membranes on plaPetition 870180001867, from 01/09/2018, p. 55/105
53/64 agar after incubation overnight at 37Ό. Figure 12 also shows approximately 50, 65 and 40 bacterial colonies in the center of the three membranes, where the 150 μΙ_ of diluted bacterial solution were previously deposited.
[00168] A fourth set of controls used the dilution of 1,000,000 times of solution of the solution as received from Escherichia coli for the deposition step. After bacterial deposition and drying, the membranes remained over the vacuum collector and were then sprayed with water, removed and dried for 5 seconds with forced air from the small fan, before being placed over the agar plate. Figure 13 shows these three membranes on the agar plate after overnight incubation at 37Ό. Figure 13 also shows 1.2 and 11 bacterial colonies in the centers of the three membranes, where those of 150 μΙ_ diluted bacterial solution were previously deposited.
[00169] These experiments establish that a diluted solution of bacteria can be deposited on the polycarbonate membranes, dried, sprayed with water, air-dried and allowed to grow on agar through overnight incubation. The average bacterial colony counts on the membranes of the fourth set of controls (1,000,000-fold dilution) is 5. The average bacterial counts on the membranes of the third set of controls (100,000-fold dilution) is 51. Based on in these counts it is expected that approximately 500 bacteria are deposited with 150 μΙ_ of the 10,000-fold dilution of the Escherichia coli solution as received.
Example 5 [00170] This example describes the inactivation of bacteria on polycarbonate membranes by briefly spraying a diluted aqueous solution of hydrogen peroxide (3%), followed by a
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54/64 quick drying. For these experiments, the deposition of bacteria on the polycarbonate membranes followed by the spraying of hydrogen peroxide solution and drying the membrane with forced air, were performed using the materials, equipment and methods described in Example 4.
[00171] A first set of membranes was prepared by depositing 150 μΙ_ of the 10,000-fold dilution of the Escherichia coli solution as received. Using the guidance of Example 4, it is estimated that 500 bacteria were deposited on each of these membranes.
[00172] An aqueous solution of hydrogen peroxide with 3% hydrogen peroxide concentration (w / v) was obtained (Walgreens, Allston, MA) and sprayed over these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards on an agar plate. Figure 14 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony was seen on these membranes indicating that all deposited bacteria were inactivated or exterminated.
[00173] A second set of membranes was prepared by depositing 150 μΙ_ of the 100,000-fold dilution of the Escherichia coli solution as received. Using the guidance of Example 4, it is estimated that 50 bacteria were deposited on each of these membranes.
[00174] An aqueous solution of hydrogen peroxide with 3% hydrogen peroxide (w / v) concentration was obtained (Walgreens, Allston, MA) and sprayed over these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards on an agar plate. Figure 15 shows these three membranes on the plate
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55/64 agar after overnight incubation at 37Ό. No bacterial colony was seen on these membranes indicating that all deposited bacteria were inactivated or exterminated [00175] A third set of membranes was prepared by depositing 150 μΙ_ of the 100,000,000-fold dilution of the Escherichia coli solution as received. Using the guidance of Example 4, it is estimated that 5 bacteria were deposited on each of these membranes.
[00176] An aqueous solution of hydrogen peroxide with 3% hydrogen peroxide concentration (w / v) was obtained (Walgreens, Allston, MA) and sprayed on these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards on an agar plate. Figure 16 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony was seen on these membranes indicating that all deposited bacteria were inactivated or exterminated.
[00177] The results of the first set of membranes in this example indicate the inactivation of approximately 500 bacteria on the membranes of this first set. This finding shows that a brief spray with the diluted aqueous solution of hydrogen peroxide (3%), followed by rapid drying, can produce at least a reduction of 2.7 in the bacterial population on the treated surface.
Example 6 [00178] This example describes the inactivation of bacteria on polycarbonate membranes by briefly spraying a diluted aqueous solution of hydrogen peroxide (1% w / v and 0.33% w / v), followed by rapid drying. For these experiments, the deposition of bacteria on the polycarbonate membranes followed by
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56/64 by spraying the hydrogen peroxide solution and drying the membrane with forced air, were performed using the materials, equipment and methods described in Example 4.
[00179] The membranes were prepared by depositing 150 μΙ_ of the 10,000-fold dilution of the Escherichia coli solution as received. Using the guidance of Example 4, it is estimated that 500 bacteria were deposited on each of these membranes.
[00180] An aqueous solution of hydrogen peroxide with 3% hydrogen peroxide concentration (w / v) was obtained (Walgreens, Allston, MA), diluted 3 times and 3 times again to provide 1% aqueous solutions (w / v) and 0.33% (w / v) of hydrogen peroxide.
[00181] The aqueous solution of 1% (w / v) of hydrogen peroxide was sprayed over a first set of membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes up over a agar plate. Figure 17 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony was seen on these membranes indicating that all deposited bacteria were inactivated or exterminated.
[00182] The aqueous solution of 0.33% (w / v) of hydrogen peroxide was sprayed over a second set of membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards. on an agar plate. Figure 18 shows these three membranes on the agar plate after overnight incubation at 37Ό. Three bacterial colonies are seen on one of the membranes while the remaining membranes each contain only one bacterial colony.
[00183] It can be noted that, despite the reduction in hydrogen peroxide concentration from 3% (w / v) to 1% (w / v) to 0.33% (w / v)
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57/64 appears to reduce the effectiveness of pathogen inactivation and extermination fluid, the 0.33% (w / v) hydrogen peroxide solution still retains substantial effectiveness.
Example 7 [00184] This example describes the inactivation of bacteria on polycarbonate membranes by briefly spraying a diluted solution of hypochlorous acid, followed by rapid drying. For these experiments, the deposition of bacteria on the polycarbonate membranes followed by spraying the hypochlorous acid solution and drying the membrane with forced air, were performed using the materials, equipment and methods described in Example 4.
[00185] A first set of membranes was prepared by depositing 150 μΙ_ of the 10,000-fold dilution of the Escherichia coli solution as received. Using the guidance of Example 4, it is estimated that 500 bacteria were deposited on each of these membranes.
[00186] An aqueous solution of hypochlorous acid with a concentration of hypochlorous acid of 0.046% was obtained (Excelyte, Integrated Environmental Technologies, LTD., Little River, SC) and sprayed over these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards over an agar plate. Figure 19 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony was seen on these membranes indicating that all deposited bacteria were inactivated or exterminated.
[00187] A second set of membranes was prepared by depositing 150 pL of the 100,000-fold dilution of the Escherichia coli solution as received. Using the guidance in Example 4, it is estimated
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58/64 that 50 bacteria were deposited on each of these membranes.
[00188] An aqueous solution of hypochlorous acid with a concentration of hypochlorous acid of 0.046% was obtained (Excelyte, Integrated Environmental Technologies, LTD., Little River, SC) and sprayed over these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards over an agar plate. Figure 20 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony is seen on the membrane at the top of the Figure, but there may be a single bacterial colony on the other two membranes shown in the Figure.
[00189] A third set of membranes was prepared by depositing 150 pL of the 1,000,000-fold dilution of the Escherichia coli solution as received. Using the guidance of Example 4, it is estimated that 5 bacteria were deposited on each of these membranes.
[00190] An aqueous solution of hypochlorous acid with a concentration of hypochlorous acid of 0.046% was obtained (Excelyte, Integrated Environmental Technologies, LTD., Little River, SC) and sprayed over these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards over an agar plate. Figure 21 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony is seen on these membranes indicating that all deposited bacteria have been inactivated.
[00191] The results of the first set of membranes in this example indicate the inactivation of approximately 500 bacteria on the membranes of this first set. This discovery shows
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59/64 that a brief spray of a dilute aqueous solution of hypochlorous acid, followed by rapid drying, can produce at least a 2.7 log reduction in the bacterial population on the treated surface.
Example 8 [00192] This example describes the inactivation of bacteria on polycarbonate membranes by briefly spraying an aqueous solution of isopropyl alcohol, followed by rapid drying. For these experiments, the deposition of bacteria on the polycarbonate membranes followed by spraying the hypochlorous acid solution and drying the membrane with forced air, were performed using the materials, equipment and methods described in Example 4.
[00193] A first set of membranes was prepared by depositing 150 μΙ_ of the 10,000-fold dilution of the Escherichia coli solution as received. Using the guidance of Example 4, it is estimated that 500 bacteria were deposited on each of these membranes.
[00194] An aqueous solution of isopropyl alcohol with an isopropyl alcohol concentration of 70% was obtained (CVS, Belmont, MA) and sprayed over these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards over an agar plate. Figure 22 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony was seen on these membranes indicating that all deposited bacteria were inactivated or exterminated.
[00195] A second set of membranes was prepared by depositing 150 μΙ_ of the 100,000-fold dilution of the Escherichia coli solution as received. Using the guidance in Example 4, it is estimated
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60/64 that 50 bacteria were deposited on each of these membranes.
[00196] An aqueous solution of isopropyl alcohol with an isopropyl alcohol concentration of 70% was obtained (CVS, Belmont, MA) and sprayed over these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards over an agar plate. Figure 23 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony was seen on these membranes indicating that all deposited bacteria were inactivated or exterminated.
[00197] A third set of membranes was prepared by depositing 150 μΙ_ of the 1,000,000-fold dilution of the Escherichia coli solution as received. Using the guidance of Example 4, it is estimated that 5 bacteria were deposited on each of these membranes.
[00198] An aqueous solution of isopropyl alcohol with 70% isopropyl alcohol concentration was obtained (CVS, Belmont, MA) and sprayed over these membranes deposited with bacteria, followed by drying with a small fan and placing the matte side of the membranes upwards over an agar plate. Figure 24 shows these three membranes on the agar plate after overnight incubation at 37Ό. No bacterial colony was seen on these membranes indicating that all deposited bacteria were inactivated or exterminated.
[00199] The results of the first set of membranes in this example indicate the inactivation of approximately 500 bacteria on the membranes of this first set. This finding shows that a brief spray of an aqueous solution of isopropyl alcohol, followed by rapid drying, can produce at least
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61/64 a reduction of 2.7 log in the bacterial population on the treated surface.
Example 9 [00200] This example describes the inactivation of bacterial spores on the polycarbonate membranes by briefly spraying an aqueous solution of hydrogen peroxide, followed by rapid drying. The aqueous solutions of hydrogen peroxide used in this example were diluted using distilled water or used as received from a solution of aqueous hydrogen peroxide (12%) (O-W & Company, Fort Collins, Colorado). The air brush used for spraying fluid is described in Example 1, together with the fan used for drying the membranes.
[00201] A solution from the Bacillus subtilis spore cell line 6633 was obtained (NAMSA, Northwood, OH) and diluted 100 times with distilled water to make a diluted spore solution containing approximately 190,000 spores per ml. Three polycarbonate membranes etched into tracks (Whatman Nucleopore, SigmaAldrich, St. Louis, MO), each 25 mm in diameter with 0.4 pm pores, were placed over a vacuum collector (Millipore, Bedford, MA). With the vacuum aspiration operating, 150 pL of the diluted spore solution was pipetted over the center of the exposed (matte) surface of each of the polycarbonate membranes. The solution was quickly drawn across the etched membrane, leaving approximately 30,000 spores on the exposed (matte) surface of each membrane. After 3 minutes of drying over the vacuum collector, the membranes were further dried by keeping each membrane under the air flow of a small fan.
[00202] These membranes deposited with spores were then placed on the surface of a pre-laboratory laboratory
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62/64 clean and, using an air brush, were sprayed with either distilled water, or a 3%, 6%, 9%, or 12% aqueous hydrogen peroxide solution for approximately 1 second and then dried for approximately 5 seconds keeping the membrane near the outlet of the small fan. It is estimated that the spraying action provided a uniform coating, based on the reflective brightness observed at the top of each membrane after each spraying. After 5 seconds of drying with the small fan, the membranes appeared to be free of all fluid and completely dry, and these were then placed on an agar plate and allowed to incubate overnight at 37Ό. The agar plates used for this example were pre-melted Luria broth (LB) agar plates (Carolina Biological Supply Company, Burlington, NC).
[00203] Figures 25A-25E show images of several membranes deposited with spores and sprayed with fluid on agar, after overnight incubation at 37Ό. Figures 2 5A-25E are described here in reverse order. As shown in panel 2501 in Figure 25E, the images show substantial bacterial growth on the membranes deposited with spores that received a brief spray of distilled water. Here, the evidence for substantial bacterial growth is the (approximately) circular, dark spot in the center of each of the circular membranes. In panel 2501, the dark spots include fields of complete bacteria, grown where the spore solution was deposited on the membranes and incubated overnight at 37Ό, after water spraying and drying.
[00204] Figure 25D (panel 2502) shows images that demonstrate substantial bacterial growth on the membranes deposited with spores that received a brief spray of an aqueous solution of 3% hydrogen peroxide. Here, the evidence
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63/64 for substantial bacterial growth is the (approximately) circular, dark spot in the center of each of the circular membranes. In Figure 25D, the dark spots include (almost) complete fields of bacteria grown after overnight incubation at 37Ό where the spore solution was deposited. Some evidence of the ability of a 3% aqueous solution of hydrogen peroxide to quickly inactivate Bacillus subtilis spores can be seen through the appearance of small but distinct dark spots within the largest dark spot in the center of each circular membrane. It is likely that these small distinct spots correspond to isolated colonies that grew from spores that were not inactivated by the brief spraying of a 3% aqueous solution (w / v) of hydrogen peroxide. The evidence for some degree of inactivation is seen in the appearance of regions that are light or free of bacteria between these small but distinct dark spots.
[00205] Figure 25C (panel 2503) does not show any bacterial growth on the membranes deposited with spores that received a brief spray of a 6% aqueous solution (w / v) of hydrogen peroxide. Figure 25B (panel 2504) does not show any bacterial growth on the membranes deposited with spores that received a brief spray of a 9% (w / v) aqueous solution of hydrogen peroxide. Finally, Figure 25A (panel 2505) does not show any bacterial growth on the membranes deposited with spores that received a brief spray of a 12% (w / v) aqueous solution of hydrogen peroxide. In panels 2503 (Figure 25C), 2504 (Figure 25B) and 2505 (Figure 25 A), the evidence for no bacterial growth, and therefore complete inactivation of bacterial spores, is shown through the absence of dark, or small, distinct spots or large and complete, in the centers of each of the membranes where
Petition 870180001867, of 01/09/2018, p. 66/105
64/64 the spore solution was deposited, before spraying the aqueous solution of hydrogen peroxide, drying and subsequent incubation overnight at 37Ό. In Figures 25A-25E, all membranes were imaged while located on top of the agar medium. This configuration allows spores that have not been inactivated to germinate and proliferate and consume nutrients from the agar through hollow holes or submicron diameter pores within each membrane.
[00206] Notably, bacterial growth is not seen on membranes deposited with spores that have been sprayed with 6%, 9% or 12% (w / v) aqueous solutions of hydrogen peroxide. The experiments, the results of which are shown in Figures 25A-25E, establish that bacterial spores on surfaces can be inactivated with a brief spray of an aqueous solution of hydrogen peroxide, followed by rapid drying.
[00207] Although the present description has been described in conjunction with various modalities and examples, it is not intended that the techniques described be limited to such modalities or examples. On the contrary, the techniques described cover several alternatives, modifications, and equivalents, as will be appreciated by those skilled in the art. Consequently, the above description and drawings are for example only.

权利要求:
Claims (38)
[1]
1. System to exterminate or inactivate a pathogen, characterized by the fact that it comprises:
a housing that has an active agent receptacle in fluid communication with at least one nozzle;
an air pump in fluid communication with at least one nozzle; and a control module configured to control the delivery of an active agent as an aerosol through at least one nozzle at a delivery dose, where the system is configured to deliver the delivery dose to a target surface as a thin coating , uniform, dry in a period of time that is less than or equal to 5 seconds.
[2]
2. System according to claim 1, characterized by the fact that it still comprises an air tank configured to provide air for at least one nozzle.
[3]
3. System according to claim 1, characterized by the fact that it also comprises a pressure regulator configured to control the pressure in at least one nozzle.
[4]
4. System according to claim 1, characterized by the fact that it still comprises a display communicatively coupled to the control module and configured to display information related to the operation of the system.
[5]
5. System according to claim 4, characterized by the fact that the display comprises an interactive display configured to receive instructions relating to the operation of the system.
[6]
6. System according to claim 1, characterized by the fact that it still comprises at least one sensor configured to detect the presence of the target surface in the vicinity of the hair
Petition 870180001867, of 01/09/2018, p. 68/105
2/5 minus a mouthpiece.
[7]
7. System according to claim 1, characterized by the fact that it also comprises a drying component configured to dry the delivery dose supplied to the target surface.
[8]
8. System according to claim 1, characterized by the fact that the active agent receptacle houses a cartridge that contains removable and refillable reagent.
[9]
9. System according to claim 1, characterized by the fact that the active agent receptacle is configured as a reservoir that receives a supply of the active agent.
[10]
10. System according to claim 1, characterized by the fact that the active agent comprises a solution selected from the group consisting of an aqueous solution of hydrogen peroxide, an aqueous solution of hypochloric acid, an aqueous solution of isopropyl alcohol, an aqueous ethanol solution, aqueous peracetic acid solution, aqueous acetic acid solution, aqueous sodium hypochlorite solution, aqueous ozone solution, and any combination thereof.
[11]
11. System according to claim 10, characterized in that the aqueous solution of hydrogen peroxide comprises from approximately 0.3% to approximately 15% of hydrogen peroxide.
[12]
12. System according to claim 11, characterized in that the aqueous solution of hydrogen peroxide comprises approximately 0.33%, 1%, 3%, 6%, 9%, or 12% hydrogen peroxide.
[13]
13. System according to claim 10, characterized in that the aqueous hypochloric acid solution comprises at least approximately 0.046% hypochloric acid.
Petition 870180001867, of 01/09/2018, p. 69/105
3/5
[14]
System according to claim 10, characterized in that the aqueous solution of isopropyl alcohol comprises at least approximately 70% of isopropyl alcohol.
[15]
15. System according to claim 1, characterized in that the active agent comprises an aqueous mixture of peracetic acid and hydrogen peroxide.
[16]
16. System according to claim 1, characterized in that the at least one nozzle comprises a single stationary nozzle.
[17]
17. System according to claim 1, characterized in that the at least one nozzle comprises two or more stationary nozzles.
[18]
18. System according to claim 1, characterized in that the at least one nozzle comprises two or more movable nozzles.
[19]
19. System according to claim 1, characterized by the fact that it still comprises at least one actuator configured to receive a user input to activate at least one nozzle.
[20]
20. System according to claim 1, characterized in that the at least one nozzle is configured to provide a uniform layer of the active agent to the target surface, the uniform layer having a thickness of approximately 1 pm approximately 50 pm.
[21]
21. System according to claim 20, characterized in that the uniform layer has a thickness of approximately 5 pm to approximately 20 pm.
[22]
22. System according to claim 1, characterized by the fact that the at least one nozzle is an ultrasonic nozzle.
[23]
23. System according to claim 1, characterized
Petition 870180001867, of 01/09/2018, p. 70/105
4/5 by the fact that the at least one nozzle comprises an atomization nozzle based on airflow.
[24]
24. System according to claim 1, characterized in that the system comprises a pressure-based fluid pump.
[25]
25. Method for exterminating or inactivating pathogens on a surface, characterized by the fact that it comprises:
spray an aerosolized layer of an active agent over the surface, the layer being a thin and substantially uniform coating, where spraying occurs over a first period of time and the aerosolized layer effective to dry over a second period of time while being effective to exterminate or inactivate the pathogen on the surface, and in which a duration of the first and second periods of time is less than 5 seconds.
[26]
26. Method according to claim 25, characterized in that the pathogens comprise bacteria, viruses, fungi, their spores or any combination thereof.
[27]
27. Method according to claim 26, characterized in that the bacterium comprises Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter, Pseudomonas aeruginosa, and Enterobacter (ESKAPE).
[28]
28. The method of claim 26, characterized in that the bacterium comprises at least one of Escherichia coli, Salmonella enterica, and Listeria monocytogenes.
[29]
29. The method of claim 26, characterized in that the viruses comprise non-enveloped viruses.
[30]
30. The method of claim 29, characterized in that the non-enveloped viruses comprise norovirus, rhinovirus, coxsackievirus, rotavirus or any combination thereof.
Petition 870180001867, of 01/09/2018, p. 71/105
5/5
[31]
31. Method according to claim 26, characterized in that the viruses comprise enveloped viruses.
[32]
32. The method of claim 31, characterized in that the enveloped viruses comprise influenza viruses.
[33]
33. The method of claim 26, characterized in that the spores comprise spores of Clostridium difficile.
[34]
34. Method according to claim 25, characterized in that the surface is a hand surface.
[35]
35. Method according to claim 25, characterized in that the duration of the first and second periods of time is less than 3 seconds.
[36]
36. Method according to claim 25, characterized in that the first period of time is approximately 1 second or less.
[37]
37. Method according to claim 25, characterized in that the second time period is approximately 2 seconds or less.
[38]
38. Method according to claim 25, characterized in that the layer of the active agent is approximately 1 pm to approximately 50 pm in thickness.

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CN108136139B|2022-03-01|

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KR20180036652A|2018-04-09|

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CN108136139A|2018-06-08|

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JP2018518341A|2018-07-12|

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EP3302659A1|2018-04-11|

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US20180161467A1|2018-06-14|

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CA2986747A1|2016-12-01|

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US20190255205A1|2019-08-22|

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WO2016191375A1|2016-12-01|

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AU2016268222A1|2017-12-07|

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EP3302659A4|2019-01-16|

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AU2016268222B2|2021-04-01|

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US10335508B2|2019-07-02|

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US9919069B2|2018-03-20|

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法律状态:
2020-06-02| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

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2021-10-13| B350| Update of information on the portal [chapter 15.35 patent gazette]|

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US201562197067P| true| 2015-07-26|2015-07-26|

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PCT/US2016/033792|WO2016191375A1|2015-05-24|2016-05-23|Systems and methods for sanitizing surfaces|

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